2 edition of Mucoadhesive polymers for targeted drug delivery to the colon found in the catalog.
Mucoadhesive polymers for targeted drug delivery to the colon
Elias P. Kakoulides
Thesis (M.Phil.) - University of Portsmouth, 1997.
|Statement||Elias P. Kakoulides.|
Review on Recent and Novel Approaches to Colon Targeted Drug Delivery Systems ABSTRACT This article focuses on the potential opportunities and inflammatory bowel disease, Crohn’s disease, colon cancer, the delivery of the drugs in the treatment of local diseases Amino acids and polymers have used as drug carriers for colon targeted delivery of 5-ASA (). Rihova used bioadhesive polymers such as HPMA copolymers that are used to mimic bioadhesive process occurring in the guinea pig GIT which are based on the presence of lectin like structures on enterocytes and in the mucus gel layer (). The physiology of the gastrointestinal tract presents serious barriers and challenges to oral drug delivery. The wide intra- and intersubject variability of gastrointestinal transit time is an important factor that can have a significant influence on drug bioavailability. Mucoadhesive formulations can increase and harmonize the passage time through the gastrointestinal tract, with the Author: Daniel Preisig. Need of colon targeted drug delivery system To ensure direct treatment at the disease site, lower dosing and fewer systemic side effects. Colon-specific formulation could also be used to prolong the drug delivery. It should be considered as beneficial in the treatment of colon diseases. The colon is aFile Size: KB.
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A novel platform system, comprising a mucoadhesive core and a rapid release carrier, was designed for targeted drug delivery to the colon. Prednisolone pellets containing different carbomers, including Carbopol P, Carbopol P and Polycarbophil AA-1, with or without organic acids, were produced by extrusion– by: Polymers for Colon Targeted Drug Delivery Article (PDF Available) in Indian Journal of Pharmaceutical Sciences 72(6) November with Reads How we measure 'reads'.
There are many advantages of using polymers as drug carriers including increasing drug stability, increasing drug solubility and having the potential to deliver targeted drugs .
The polymers. Title:Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review VOLUME: 18 ISSUE: 34 Author(s):Jose’ Bagan, Carlo Paderni, Nicoletta Termine, Giuseppina Campisi, Lucio Lo Russo, Domenico Compilato and Olga Di Fede Affiliation:Professor of Oral Medicine- Valencia an Service of Stomatology.
University General Hospital. The application of mucoadhesive polymers in nasal drug delivery systems has gained to promote dosage form residence time in the nasal cavity as well as improving intimacy of contact with absorptive membranes of the biological system.
The various new technology uses in development of nasal drug delivery dosage forms are discussed. Successful delivery of a drug to the colon requires protection of the drug from degradation or release in the stomach and then controlled release of drug in colon[3,4].
The desired properties of colon targeted drug delivery systems can be achieved by using some polymers either alone or in a combination because it is now recognized that polymers. The aim of this Special Issue is to present recent advances in the area of mucoadhesive polymers and formulations.
(GG:P) biodegradable mucoadhesive beads intended for the colon-targeted delivery of resveratrol (RES). The impact of the polymer carrier system on the cytotoxicity and permeability of RES was evaluated. Mucoadhesive drug.
Formulation and evaluation of colon targeted drug delivery system Ranjit Singh Department of Pharmaceutics, KMCH College of Pharmacy, Kovai Estate, Coimbatore, (T.N.) - India Abstract The main objective of the present study was to develop colon targeted drug delivery systems for Nitrofurantoin using guar gum as a carrier.
Mucoadhesive polymers for targeted drug delivery to the colon book This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa).
Mucoadhesive drug delivery systems 3 the contact between the mucoadhesive and the mucous membrane, with spreading and swelling of the formu-lation, initiating its deep contact with the mucus layer (Hägerstrom, ).
In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane. Novel Mucoadhesive Polymers –A Review Mythri.G, K. Kavitha, M. Rupesh Kumar, Sd. Jagadeesh Singh The mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism.
Rajpurohit, et al.: Polymers for Colon Targeted Drug Delivery The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy.
Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Mucoadhesive Drug Delivery System - Nasal - Khan Halimunnisa, Hastak Vishakha 9.
Mucoadhesive Drug Delivery System - Rectal - Kulkarni Akshasa, Pawar Yogesh Mucoadhesive Drug Delivery System - Vaginal - Deshpande Tanvee, Shinde Rohit, Pawar Yogesh Parenteral Controlled Drug Delivery System – cines pose potential candidature for colon targeted drug delivery.
Methods. The various strategies for targeting orally administered drugs to the colon include covalent linkage of a drug with a carrier, coating with pH-sensitive polymers, formulation of timed released systems, exploita-tion of carriers that are degraded specifically by colonic.
Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract.
In recent years, the global pharmaceutical market for biologics has Author: Sang Hoon Lee, Rajiv Bajracharya, Jeong Youn Min, Ji-Won Han, Byeong Ju Park, Hyo-Kyung Han.
Mucoadhesive Polymers. Another strategy to increase the GI retention time, which would further improve the oral bioavailability of insulin, is the development of delivery devices. These delivery devices are mucoadhesive polymers.
Mucoadhesion refers to adhesion between a material and mucosal surface by means of interfacial forces. Mucoadhesive polymers have the ability to adhere to the mucus layer covering those surfaces and by that promote drug release, targeting and absorption.
Mucoadhesive polymers commonly interact with mucus through non-covalent bonds such as Cited by: 1. of polymers in drug delivery will grow steeply in future to handle various unsolved issues.
These issues may in-clude site specific drug delivery in subcellular organelles, harnessing chemical, physical and biological proper-ties efficiently to optimize drug administrations. Nano composites have shown to penetrate deep blood brain barriers .File Size: 1MB.
• Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption. • Mucoadhesive drug delivery system is a part of controlled delivery system.
3 4. Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery.
Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of Cited by: All major routes of drug delivery have been covered to provide the reader with a panoramic as well as an in-depth view of the developments in polymer-based drug delivery systems.
Appendices are included which incorporate useful pharmaceutical properties of the polymers and important polymeric applications for various drug delivery : Hardcover. This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development tes the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of 5/5(1).
mucoadhesive polymers can also modulate the permeability of epithelial tissues by loosening the tight intercellular junctions , and that some mucoadhesive polymers can also act as inhibitors of proteolytic enzymes .
Over the last 30 years, the market share of transmucosal drug delivery systems has. Mucoadhesion describes the attractive forces between a biological material and mucus or mucous membrane.
Mucous membranes adhere to epithelial surfaces such as the gastrointestinal tract (GI-tract), the vagina, the lung, the eye, etc. They are generally hydrophilic as they contain many hydrogen macromolecules due to the large amount of water (approximately 95%) within its composition.
with the mucous membranes. The present review describes mucoadhesion, mucoadhesive polymers and use of these polymers in designing different types of mucoadhesive gastrointestinal, nasal, ocular, vaginal and rectal drug delivery systems.
This also focuses on mucoadhesive drug delivery systems available in. synthetic surface. In case of bioadhesive drug delivery, the term bioadhesion is used to describe the adhesion between polymers, either synthetic or natural and soft tissues or the gastrointestinal mucosa.
In cases where the bond is formed with the mucus the term mucoadhesion may be used synonymously with bioadhesion.
Buccal delivery. About Authors: Saumya Samanta1, Ranabir Chanda2, Jyotishman Bhattacharya3 Benagal School of Technology, Chuchura, West Bengal, India *[email protected] ABSTRACT Formulations of mucoadhesive polymers are of current interest in the design of drug delivery systems.
Current uses of mucoadhesive based preparations include ophthalmic solutions, local applications to treat. Mucoadhesive drug delivery system (MDDS): MDDS utilizes the property of bioahesion of certain water-soluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time.
Takeuchi H, Thongborisute J, Matsui Y, Sugihara H, Yamamoto H, Kawashima Y () Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems.
Adv Drug Deliv Rev – PubMed CrossRef Google ScholarCited by: Azo polymeric new drug In which use of polymers as drug carriers for drug delivery to colon. Synthetic, naturally, sub-synthetic polymers used form colon targeted polymeric prodrug with azo linkage between polymer & drug moiety.
The various azo polymers are evaluated for coating materials over drug are susceptible to cleavage by azo. This book focuses on defining the principles of bioadhesive delivery systems based on hydrogels to biological surfaces that are covered by mucus.
An overview of the last decade’s discoveries on mucoadhesion and applications of mucoadhesive hydrogels as drug carriers is : N.V. Satheesh Madhav, Pranshu Tangri. The current review article focuses on polymers in pharmaceutical drug delivery of therapeutic agents.
These dosage forms include tablets, patches, tapes, films, semisolids and powders. Polymers are the backbone of a pharmaceutical drug delivery system as they. Stomach Specific Mucoadhesive-A Review.
About Authors: Shalini Sharma, Manoj Prashar By using the concepts and technique of controlled and targeted drug delivery system the above problems can be overcome. In controlled drug delivery system the drug release locally or systemically at a predetermined rate for a predetermined period of time.
Approaches used for site specific drug delivery to colon Primary approaches for CDDS Microbial triggered colon targeted drug delivery system: The human colon is a dynamic and ecologically diverse environment containing over distinct species of bacteria with a population Cited by: 1. Hence mucoadhesive polymers can be used as means of improving drug delivery PowerPoint Presentation: References Yie in Novel Drug Delivery System Michael J Rathbone, in: Oral Mucosal Drug Delivery Hitesh R.
Patel, Dr. M.M. Patel, in: Draw Attention Towards Mucoadhesive Buccal Drug Delivery System Donald L. Wise,Handbook of. Additional interest in colon targeted drug delivery system has generated from the potential of the colonic site for the entry of some drugs into the systemic circulation.
The colonic region is believed to contain lower levels of luminal and mucosal digestive enzymes in comparison with stomach and small intestine [. bond.
The carriers, which contain additives like polymers (may be used as matrices and hydro gels or coating agents) may influence the release properties and efficacy of the systems Approaches used for Site Specific Drug Delivery to Colon (CDDS) Several approaches are.
ABSTRACT: This review highlights the development of mucoadhesive polymers in buccal delivery of the desired drug using mucoadhesive polymers has been the subject of interest since the early s.
Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of Size: KB. First generation mucoadhesive polymers • Anionic polymers (polyacrylic acids- carbomers, sodium alginate) • Cationic polymers (chitosan) • Non-ionic polymers (cellulose derivatives) hydroxyl, carboxyl or amine groups on the molecules favours adhesion Formulation challenges due to hydrophilicity and limited solubility in other solvents.
(Mucoadhesive polymers, polymers controlling rate of release and Polymers to prepare backing membrane): As the contact between the formulation and the buccal mucosa is one of the key factors in successful buccal delivery, more emphasis is now given to the use of mucoadhesive polymers in the formulation of buccal drug delivery systems.
Mucoadhesive and pH-sensitive ovalbumin (OVA)-loaded NPs as well as NPs for sustained drug delivery have been obtained from trimethylchitosan (TMC), Eudragit ® S and a polymer mixture (PLGA, PEG-PLGA and PEG-PCL), respectively, for a target colon delivery to the inflamed tissues.
Mannose or a specific peptide has been grafted on the Cited by: 3.Formulation scientists have structured and engineered several mucoadhesive polymers for their usefulness in enhancement of bioavailability, controlled and targeted drug delivery.
Mucoadhesive polymers can be classified as non-specific first generation polymers and novel second generation polymers based on the mechanism of by: Targeted delivery combined with controlled drug release has a pivotal role in the future of personalized medicine.
This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways.